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Combination drug From Wikipedia, the free encyclopedia
Nifurtimox/eflornithine is a combination of two antiparasitic drugs, nifurtimox and eflornithine, used in the treatment of African trypanosomiasis (sleeping sickness).[1][2] It is included in the World Health Organization's Model List of Essential Medicines.[3]
Combination of | |
---|---|
Nifurtimox | antiparasitic agent |
Eflornithine | antiparasitic agent |
A treatment regimen known as nifurtimox-eflornithine combination treatment (NECT) is used in second stage gambiense African trypanosomiasis throughout Africa where the disease is endemic.[4] The regimen involves slow infusion of 400 mg of eflornithine every 12 hours for 7 days combined with 15 mg/kg of nifurtimox orally three times a day for 10 days.[4]
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