Nitrazepam
Benzodiazepine sedative / From Wikipedia, the free encyclopedia
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Nitrazepam, sold under the brand name Mogadon among others,[2][3] is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia.[4] It also has sedative (calming) properties,[5] as well as amnestic (inducing forgetfulness), anticonvulsant, and skeletal muscle relaxant effects.
Quick Facts Clinical data, Trade names ...
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Trade names | Alodorm, Apodorm, Arem, Cerson, Insoma, Insomin, Mogadon, Nitrados, Nitrazadon, Nitrosun, Nitravet, Ormodon, Paxadorm, Remnos, Epam, and Somnite |
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Dependence liability | Physical: High Psychological: Moderate |
Addiction liability | Moderate |
Routes of administration | Oral |
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Bioavailability | 53–94% |
Metabolism | Hepatic |
Elimination half-life | 16–38 hours |
Excretion | Renal |
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ECHA InfoCard | 100.005.151 |
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Formula | C15H11N3O3 |
Molar mass | 281.271 g·mol−1 |
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It was first synthesized in the late 1950s by a team of researchers at Hoffmann-La Roche in Switzerland.[6] It was patented in 1961 and came into medical use in 1965.[7]