Original antigenic sin
Immune phenomenon / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Original antigenic sin?
Summarize this article for a 10 year old
Original antigenic sin, also known as antigenic imprinting, the Hoskins effect,[1] immunological imprinting,[2] or primary addiction[3] is the propensity of the immune system to preferentially use immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to repertoire freeze, a form of original antigenic sin.
The phenomenon has been described in relation to influenza virus, SARS-CoV-2,[2] dengue fever, human immunodeficiency virus (HIV) [4] and to several other viruses.[5]