PSB-SB-487
Chemical compound / From Wikipedia, the free encyclopedia
PSB-SB-487 is a coumarin derivative which is an antagonist at the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487 has good selectivity over the related receptor GPR18, with an IC50 of 113nM at GPR55 vs 12500nM at GPR18.[1] However it has poorer selectivity over other related receptors, acting as a weak antagonist at CB1 with a Ki of 1170nM, and a partial agonist at CB2 with a Ki of 292nM.[2]
Quick Facts Identifiers, PubChem CID ...
Identifiers | |
---|---|
| |
PubChem CID | |
ChemSpider | |
Chemical and physical data | |
Formula | C26H32O4 |
Molar mass | 408.538 g·mol−1 |
3D model (JSmol) | |
| |
|
Close