PX domain
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The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
Quick Facts Identifiers, Symbol ...
Identifiers | |||||||||
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Symbol | PX | ||||||||
Pfam | PF00787 | ||||||||
InterPro | IPR001683 | ||||||||
SMART | PX | ||||||||
PROSITE | PDOC50195 | ||||||||
SCOP2 | 1h6h / SCOPe / SUPFAM | ||||||||
OPM superfamily | 57 | ||||||||
OPM protein | 1xte | ||||||||
CDD | cd06093 | ||||||||
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This domain was first found in P40phox and p47phox domains of NADPH oxidase (phox stands for phagocytic oxidase).[1][2] It was also identified in many other proteins involved in membrane trafficking, including nexins, Phospholipase D, and phosphoinositide-3-kinases.
The PX domain is structurally conserved in eukaryotes, although amino acid sequences show little similarity.[3] PX domains interact primarily with PtdIns(3)P lipids.[4][5] However some of them bind to phosphatidic acid, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns(4,5)P2, and PtdIns(3,4,5)P3. The PX-domain can also interact with other domains and proteins.