Parathyroid hormone receptor
From Wikipedia, the free encyclopedia
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]
- parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
- parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]
Quick Facts Identifiers, Symbol ...
parathyroid hormone 1 receptor | |||||||
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Identifiers | |||||||
Symbol | PTH1R | ||||||
Alt. symbols | PTHR, PFE | ||||||
NCBI gene | 5745 | ||||||
HGNC | 9608 | ||||||
OMIM | 168468 | ||||||
RefSeq | NM_000316 | ||||||
UniProt | Q03431 | ||||||
Other data | |||||||
Locus | Chr. 3 p22-p21.1 | ||||||
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Quick Facts Identifiers, Symbol ...
parathyroid hormone 2 receptor | |||||||
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Identifiers | |||||||
Symbol | PTH2R | ||||||
NCBI gene | 5746 | ||||||
HGNC | 9609 | ||||||
OMIM | 601469 | ||||||
RefSeq | NM_005048 | ||||||
UniProt | P49190 | ||||||
Other data | |||||||
Locus | Chr. 2 q33 | ||||||
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