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Philippa Marrack

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Philippa Marrack
Born (1945-06-28) 28 June 1945 (age 74)
Ewell, England
Other namesPippa Marrack
Alma materNew Hall, Cambridge (University of Cambridge) (M.A., Ph.D)
Known fordiscovery of T cell receptor, discovery of superantigens, T cells, autoimmune disease
Spouse(s)John W. Kappler
AwardsMember, National Academy of Sciences (1989)

Louisa Gross Horwitz Prize (1995)
Dickson Prize (1996)
Fellow, Royal Society (1997)
L'Oréal-UNESCO Award for Women in Science (2004)

National Women's Hall of Fame (2015)
Scientific career
FieldsImmunology
InstitutionsUniversity of California, San Diego
University of Rochester
National Jewish Health
University of Colorado Denver
HHMI
Doctoral advisorAlan Munro
WebsiteKM lab website

Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English immunologist and academic, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.[1] She collaborates with her husband, John W. Kappler.[2]

Biography

Dr. Marrack was born in Ewell, England on 28 June 1945.[3][unreliable source?] She completed both undergraduate (1967) and PhD (1970) work at New Hall, Cambridge. During her PhD, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to study the differences between T cells and B cells.

She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado. She is Howard Hughes Medical Institute investigator.[4]

She collaborates with her husband John W. Kappler. They met in 1971 as postdoctoral fellows at the University of California San Diego[5]. In 1983 they discovered the T cell receptor, together with Ellis Reinherz and James Allison.

She attributes her interest in immunology to her great uncle British pathologist John Marrack.[5][6]

Marrack plays the piano and is a blues guitarist.[5]

Professional Activities

Dr. Marrack served as president of the American Association of Immunologists (AAI) from 2000 to 2001 and the AAI Council from 1995 to 2002.[4]

Significant papers

  • J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
  • P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
  • J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
  • J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).
  • J.W. Kappler, et al. "Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition." Journal of Experimental Medicine 153.5 (1981): 1198-1214.

Awards

This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: check if all these awards are notable. Please help improve this article if you can. (January 2020) (Learn how and when to remove this template message)

References

  1. ^ Rennie, J. (1992) "Profile: Philippa Marrack and John Kappler – Keeping It In the Family", Scientific American 267(2), 43–44.
  2. ^ International who's who of women 2014. Europa Publications Limited. London. ISBN 9781857436945. OCLC 855705836.CS1 maint: others (link)
  3. ^ Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191. ISBN 978-1-4381-0795-0.
  4. ^ a b c d "Philippa Marrack, Ph.D." American Association of Immunologists. Retrieved 29 January 2020.
  5. ^ a b c Powell, Kendall (December 2004). "Profile: Philippa Marrack". Nature Medicine. 10: 1270.
  6. ^ Immunologists, The Amer Assn of (26 April 2013), Philippa Marrack, Ph.D. (AAI '74, president 2000–2001), retrieved 30 January 2020
  7. ^ "Philippa Marrack". Retrieved 3 May 2019. Text " American Academy of Arts and Sciences " ignored (help)
  8. ^ "M. D. Anderson Cancer Center - Current Research/Awards". www3.mdanderson.org. Retrieved 24 November 2019.
  9. ^ "Announcement". Immunology. 78:3: 511. March 1993 – via EBSCO Academic Search Complete.
  10. ^ "Horwitz Prize Awardees". Columbia University Irving Medical Center. 20 June 2018. Retrieved 24 November 2019.
  11. ^ "Bonnie Bassler, PhD". www.dicksonprize.pitt.edu. Retrieved 24 November 2019.
  12. ^ "The Rabbi Shai Shaknai Award - מרכז לאוטנברג לאימונולוגיה וחקר הסרטן | Lautenberg Center for Immunology and Cancer research". מרכז לאוטנברג לאימונולוגיה וחקר הסרטן | Lautenberg Center for Immunology and Cancer research. Retrieved 24 November 2019.
  13. ^ "Dr Philippa Marrack | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 24 November 2019.
  14. ^ "Philippa Marack To Be Honored for Lifetime Achievement in Immunology", 4 May 2003.
  15. ^ "AAI Award History". aai.org.
  16. ^ sean. "Past Honorees". Bonfils-Stanton Foundation. Retrieved 24 November 2019.
  17. ^ Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", 2 November 2005.
  18. ^ "Deutscher Immunologiepreis" (in German). Retrieved 24 November 2019.
  19. ^ "Member Directory - Philippa Marrack, Ph.D." National Academy of Medicine.
  20. ^ Colorado Women's Hall of Fame, Philippa Marrack, PhD
  21. ^ Siegel-Itzkovich, Judy (29 January 2015). "Wolf Prizes in the sciences and arts presented to nine North Americans". The Jerusalem Post. Retrieved 5 May 2016.
  22. ^ Marisa Zeppieri-Caruana. "10 women honored at Hall of Fame induction". Democratandchronicle.com. Retrieved 4 October 2015.
  23. ^ National Women's Hall of Fame. "Marrack, Philippa – National Women's Hall of Fame". womenofthehall.org. Retrieved 13 February 2017.
  24. ^ "Marrack, Philippa". National Women’s Hall of Fame. Retrieved 30 January 2020.
  25. ^ "Six leading scientists to receive prestigious Novartis Prizes for Immunology at 16th International Congress of Immunology". Novartis. Retrieved 24 November 2019.
  26. ^ "Researchers of Nobel class: Citation Laureates 2019". Web of Science Group. Retrieved 24 November 2019.

Further reading

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