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Protein family From Wikipedia, the free encyclopedia
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).[1]
The human PIKK family includes six members:
Gene | Protein | Function |
---|---|---|
ATM | ataxia-telangiectasia mutated | response to DNA damage |
ATR | ataxia- and Rad3-related | " |
PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PKcs) | " |
MTOR | mammalian target of rapamycin (mTOR) | nutrient-regulated kinase that controls metabolism and cell growth |
SMG1 | suppressor of morphogenesis in genitalia | regulates nonsense-mediated mRNA decay |
TRRAP | transformation/transcription domain-associated protein | transcription factor co-activator |
PIKKs proteins contain the following four domains:
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