Phosphoglycerate dehydrogenase
Metabolic enzyme PHGDH / From Wikipedia, the free encyclopedia
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Phosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyzes the chemical reactions
- 3-phospho-D-glycerate + NAD+ 3-phosphonooxypyruvate + NADH + H+
- 2-hydroxyglutarate + NAD+ 2-oxoglutarate + NADH + H+
Quick Facts PHGDH, Available structures ...
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Quick Facts Identifiers, EC no. ...
phosphoglycerate dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.95 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The two substrates of this enzyme are 3-phospho-D-glycerate and NAD+, whereas its 3 products are 3-phosphohydroxypyruvate, NADH, and H+
It is also possible that two substrates of this enzyme are 2-hydroxyglutarate and NAD+, whereas its 3 products are 2-oxoglutarate, NADH, and H+.
As of 2012, the most widely studied variants of PHGDH are from the E. coli and M. tuberculosis genomes.[5] In humans, this enzyme is encoded by the PHGDH gene.[6]