Propionyl-CoA
Chemical compound / From Wikipedia, the free encyclopedia
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Propionyl-CoA is a coenzyme A derivative of propionic acid. It is composed of a 24 total carbon chain (without the coenzyme, it is a 3 carbon structure) and its production and metabolic fate depend on which organism it is present in.[1] Several different pathways can lead to its production, such as through the catabolism of specific amino acids or the oxidation of odd-chain fatty acids.[2] It later can be broken down by propionyl-CoA carboxylase or through the methylcitrate cycle.[3] In different organisms, however, propionyl-CoA can be sequestered into controlled regions, to alleviate its potential toxicity through accumulation.[4] Genetic deficiencies regarding the production and breakdown of propionyl-CoA also have great clinical and human significance.[5]
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IUPAC name
3′-O-Phosphonoadenosine 5′-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl dihydrogen diphosphate} | |
Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl} O3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate | |
Other names
Propionyl Coenzyme A; Propanoyl Coenzyme A | |
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ChEBI | |
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ECHA InfoCard | 100.005.698 |
MeSH | propionyl-coenzyme+A |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C24H40N7O17P3S | |
Molar mass | 823.60 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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