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InterPro Family From Wikipedia, the free encyclopedia
The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
receptor/gene | ligands | activates | inhibits |
---|---|---|---|
RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
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