SB-649,915

SB-649,915
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 6-[(1-[3-(2-methylquinolin-5-yl)oxypropyl]piperidin-4-yl)methyl]-4H-1,4-benzoxazin-3-one;
CAS Number	420785-70-2 ;
PubChem CID	10225553;
IUPHAR/BPS	76;
ChemSpider	8471882 ;
UNII	HD3UV2MFJ8;
ChEMBL	ChEMBL183460 ;
Chemical and physical data
Formula	C26H29N3O3
Molar mass	431.536 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4COc1ccc(cc1N4)CC(CC5)CCN5CCOc(cccc2n3)c2ccc3C;
	InChI InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30) ; Key:PJSUYRBCBFPCQW-UHFFFAOYSA-N ;
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SB-649,915 is a serotonin reuptake inhibitor and 5-HT_1A and 5-HT_1B receptor antagonist which is being investigated for its antidepressant effects.^[1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well.^[1] This can be attributed to blockade of 5-HT_1A and 5-HT_1B autoreceptors which inhibit serotonin release.^[1]

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Clinical data

ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 6-[(1-[3-(2-methylquinolin-5-yl)oxypropyl]piperidin-4-yl)methyl]-4H-1,4-benzoxazin-3-one
CAS Number	420785-70-2^N
PubChem CID	10225553
IUPHAR/BPS	76
ChemSpider	8471882^N
UNII	HD3UV2MFJ8
ChEMBL	ChEMBL183460^N
Chemical and physical data
Formula	C₂₆H₂₉N₃O₃
Molar mass	431.536 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C4COc1ccc(cc1N4)CC(CC5)CCN5CCOc(cccc2n3)c2ccc3C
InChI InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30)^N Key:PJSUYRBCBFPCQW-UHFFFAOYSA-N^N
^NY (what is this?) (verify)