Zinc transporter ZIP10

Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene.^[5] ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.^[5][6]

SLC39A10
Identifiers
Aliases	SLC39A10, LZT-Hs2, solute carrier family 39 member 10
External IDs	OMIM: 608733; MGI: 1914515; HomoloGene: 34076; GeneCards: SLC39A10; OMA:SLC39A10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.3 Start 195,575,977 bp[1] End 195,737,702 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 46,846,704 bp[2] End 46,932,012 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus secondary oocyte Brodmann area 46 superior frontal gyrus Brodmann area 23 germinal epithelium postcentral gyrus right lobe of thyroid gland dorsolateral prefrontal cortex Brodmann area 9 Top expressed in hand hair follicle otolith organ utricle secondary oocyte primitive streak primary motor cortex cingulate gyrus piriform cortex primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process metal ion transport negative regulation of B cell apoptotic process positive regulation of protein tyrosine phosphatase activity zinc ion transport ion transport positive regulation of B cell proliferation transmembrane transport cellular zinc ion homeostasis positive regulation of B cell receptor signaling pathway zinc ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57181 227059 Ensembl ENSG00000196950 ENSMUSG00000025986 UniProt Q9ULF5 Q6P5F6 RefSeq (mRNA) NM_001127257 NM_020342 NM_172653 NM_001356416 NM_001356417 RefSeq (protein) NP_001120729 NP_065075 NP_766241 NP_001343345 NP_001343346 Location (UCSC) Chr 2: 195.58 – 195.74 Mb Chr 1: 46.85 – 46.93 Mb PubMed search [3] [4]
Wikidata
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References

1. GRCh38: Ensembl release 89: ENSG00000196950 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025986 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Taylor KM, Morgan HE, Smart K, Zahari NM, Pumford S, Ellis IO, Robertson JF, Nicholson RI (Jul–Aug 2007). "The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer". Mol Med. 13 (7–8): 396–406. doi:10.2119/2007-00040.Taylor. PMC 1936980. PMID 17673939.
6. Eide DJ (February 2004). "The SLC39 family of metal ion transporters". Pflügers Arch. 447 (5): 796–800. doi:10.1007/s00424-003-1074-3. PMID 12748861. S2CID 11765308.

Further reading

• Wang L, McDonnell SK, Hebbring SJ, et al. (2008). "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. doi:10.1158/1055-9965.EPI-08-0434. PMC 2750891. PMID 19064571.