SLC45A1 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can:
(i) transport a disaccharide, such as glucose and sucrose
(ii) perform secondary active transport in a proton-dependent manner.[5]
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It is associated with sugar transport in the brain, and rare mutations in the gene are associated with intellectual disability and epilepsy.[6] analogous to the effect of mutation of the cerebral glucose transporter GLUT1(SLC2A1).