Sodium/hydrogen exchanger 5

Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.^[5][6][7]

SLC9A5
Identifiers
Aliases	SLC9A5, NHE5, solute carrier family 9 member A5
External IDs	OMIM: 600477; MGI: 2685542; HomoloGene: 31247; GeneCards: SLC9A5; OMA:SLC9A5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,237,683 bp[1] End 67,272,191 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,348,843 bp[2] End 105,369,881 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum spleen stromal cell of endometrium nucleus accumbens putamen caudate nucleus cerebellar vermis testicle right frontal lobe dorsal motor nucleus of vagus nerve Top expressed in spermatocyte superior frontal gyrus cerebellar cortex neural layer of retina primary visual cortex lumbar subsegment of spinal cord seminiferous tubule tail of embryo ventricular zone cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function solute:proton antiporter activity antiporter activity potassium:proton antiporter activity sodium:proton antiporter activity Cellular component membrane integral component of membrane plasma membrane Biological process regulation of pH ion transport proton transmembrane transport sodium ion transport cation transport regulation of intracellular pH sodium ion import across plasma membrane potassium ion transmembrane transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6553 277973 Ensembl ENSG00000135740 ENSMUSG00000014786 UniProt Q14940 B2RXE2 RefSeq (mRNA) NM_004594 NM_001323971 NM_001323972 NM_001323973 NM_001323974 NM_001323975 NM_001081332 RefSeq (protein) NP_001310900 NP_001310901 NP_001310902 NP_001310903 NP_001310904 NP_004585 NP_001074801 Location (UCSC) Chr 16: 67.24 – 67.27 Mb Chr 8: 105.35 – 105.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000135740 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014786 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.
6. Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi:10.1074/jbc.274.7.4383. PMID 9933642.
7. "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

Further reading

• Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain". J. Biol. Chem. 274 (7): 4377–82. doi:10.1074/jbc.274.7.4377. PMID 9933641.
• Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton". J. Biol. Chem. 277 (45): 42623–32. doi:10.1074/jbc.M206629200. PMID 12205089.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
• Lin WM, Chen XH, Xu R, et al. (2003). "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao: [Acta Physiologica Sinica]. 55 (1): 79–82. PMID 12598940.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790–5. Bibcode:2005PNAS..102.2790S. doi:10.1073/pnas.0407444102. PMC 549460. PMID 15699339.
• Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity". Cell. Signal. 19 (1): 194–203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.