Sarcospan
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Sarcospan is a protein that in humans is encoded by the SSPN gene.
Quick Facts SSPN, Identifiers ...
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Aliases | SSPN, DAGA5, KRAG, NSPN, SPN1, SPN2, sarcospan | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601599 MGI: 1353511 HomoloGene: 3727 GeneCards: SSPN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Originally identified as Kirsten ras associated gene (KRAG), sarcospan is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells, where it is most abundant. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[5] Loss of SSPN expression occurs in patients with Duchenne muscular dystrophy. Dystrophin is required for proper localization of SSPN. SSPN is also an essential regulator of Akt signaling pathways. Without SSPN, Akt signaling pathways will be hindered and muscle regeneration will not occur.