Semustine
Chemical compound / From Wikipedia, the free encyclopedia
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Semustine (1- (2-Chloroethyl)-3-(trans-4-methylcyclohexyl)- 1-nitrosourea, MeCCNU) is an alkylating nitrosourea compound used in chemotherapy treatment of various types of tumours.[1][2] Due to its lipophilic property, semustine can cross the blood-brain barrier for the chemotherapy of brain tumours, where it interferes with DNA replication in the rapidly-dividing tumour cells.[2] Semustine, just as lomustine, is administered orally. Evidence has been found that treatment with semustine can cause acute leukaemia as a delayed effect in very rare cases.[3]
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ECHA InfoCard | 100.162.271 |
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Formula | C10H18ClN3O2 |
Molar mass | 247.72 g·mol−1 |
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