Shaker (gene)
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The shaker (Sh) gene, when mutated, causes a variety of atypical behaviors in the fruit fly, Drosophila melanogaster.[1][2][3][4] Under ether anesthesia, the fly’s legs will shake (hence the name); even when the fly is unanaesthetized, it will exhibit aberrant movements. Sh-mutant flies have a shorter lifespan than regular flies; in their larvae, the repetitive firing of action potentials as well as prolonged exposure to neurotransmitters at neuromuscular junctions occurs.
Quick Facts Identifiers, Organism ...
Shaker | |||||||
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Identifiers | |||||||
Organism | Drosophila melanogaster | ||||||
Symbol | Sh | ||||||
Entrez | 32780 | ||||||
RefSeq (mRNA) | NM_167596 | ||||||
UniProt | P08510 | ||||||
Other data | |||||||
Chromosome | X: 17.8 - 17.98 Mb | ||||||
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Quick Facts potassium voltage-gated channel, shaker-related subfamily, member 3, Identifiers ...
potassium voltage-gated channel, shaker-related subfamily, member 3 | |||||||
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Identifiers | |||||||
Symbol | KCNA3 | ||||||
NCBI gene | 3738 | ||||||
HGNC | 6221 | ||||||
OMIM | 176263 | ||||||
RefSeq | NM_002232 | ||||||
UniProt | P22001 | ||||||
Other data | |||||||
Locus | Chr. 1 p13.3 | ||||||
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In Drosophila, the shaker gene is located on the X chromosome. The closest human homolog is KCNA3.[5]