Farnesyl-diphosphate farnesyltransferase
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Squalene synthase (SQS) or farnesyl-diphosphate:farnesyl-diphosphate farnesyl transferase is an enzyme localized to the membrane of the endoplasmic reticulum. SQS participates in the isoprenoid biosynthetic pathway, catalyzing a two-step reaction in which two identical molecules of farnesyl pyrophosphate (FPP) are converted into squalene, with the consumption of NADPH.[2] Catalysis by SQS is the first committed step in sterol synthesis, since the squalene produced is converted exclusively into various sterols, such as cholesterol, via a complex, multi-step pathway. SQS belongs to squalene/phytoene synthase family of proteins.
Quick Facts Squalene synthase, Identifiers ...
Squalene synthase | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.21 | ||||||||
CAS no. | 9077-14-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
farnesyl-diphosphate farnesyltransferase 1 | |||||||
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Identifiers | |||||||
Symbol | FDFT1 | ||||||
NCBI gene | 2222 | ||||||
HGNC | 3629 | ||||||
OMIM | 184420 | ||||||
RefSeq | NM_004462 | ||||||
UniProt | P37268 | ||||||
Other data | |||||||
EC number | 2.5.1.21 | ||||||
Locus | Chr. 8 p23.1-p22 | ||||||
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