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Chemical compound From Wikipedia, the free encyclopedia
Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is an intermediate in the biosynthesis of terpenes and terpenoids such as sterols and carotenoids.[1] It is also used in the synthesis of CoQ (part of the electron transport chain), as well as dehydrodolichol diphosphate (a precursor of dolichol, which transports proteins to the ER lumen for N-glycosylation).
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Preferred IUPAC name
(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate | |
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ChemSpider | |
MeSH | farnesyl+pyrophosphate |
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CompTox Dashboard (EPA) |
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Properties | |
C15H28O7P2 | |
Molar mass | 382.330 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Farnesyl pyrophosphate synthase (a prenyl transferase)[2] catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two steps:
The above reactions are inhibited by bisphosphonates (used for osteoporosis).[3] Farnesyl pyrophosphate is a selective agonist of TRPV3.[4]
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