TREM2
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene.[5][6][7] TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia,[8] which are immune cells in the central nervous system.[9] In the liver, TREM2 is expressed by several cell types, including macrophages, that respond to injury.[10] In the intestine, TREM2 is expressed by myeloid-derived dendritic cells and macrophage.[11] TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target.
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