Tedatioxetine (developmental code name Lu AA24530) is an experimental antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.[1]
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Other names | Lu AA24530; Lu-AA-24530 |
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Formula | C18H21NS |
Molar mass | 283.43 g·mol−1 |
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Tedatioxetine is reported to act as a triple reuptake inhibitor (serotonin > norepinephrine > dopamine) and 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptor antagonist.[2][3][4][5]
As of 2009, it was in phase II clinical trials for major depressive disorder,[5] but there have been no updates since then, and as of August 2013 it was no longer displayed on Lundbeck's product pipeline.[6][7]
On May 10, 2016, all work on tedatioxetine stopped.[8]
A Chinese patent shows that there has been interest in this compound outside of Lundbeck.[9]
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