Testosterone enanthate
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Testosterone enanthate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men.[3][4][5] It is also used in hormone therapy for transgender men.[6] It is given by injection into muscle or subcutaneously usually once every one to four weeks.[5][7][2]
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Trade names | Delatestryl, Xyosted, others |
Other names | TE; Testosterone heptanoate; Testosterone 17β-heptanoate; NSC-17591 |
Routes of administration | Intramuscular injection, subcutaneous injection |
Drug class | Androgen; Anabolic steroid; Androgen ester |
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Bioavailability | Oral: very low Intramuscular: high |
Metabolism | Liver |
Elimination half-life | Intramuscular: 4–5 days[2] |
Excretion | Urine |
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ECHA InfoCard | 100.005.686 |
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Formula | C26H40O3 |
Molar mass | 400.603 g·mol−1 |
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Side effects of testosterone enanthate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[5] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[8][5] Testosterone enanthate is a testosterone ester and a long-lasting prodrug of testosterone in the body.[7][3][4] Because of this, it is considered to be a natural and bioidentical form of testosterone,[9] which make it useful for producing masculinization and suitable for androgen replacement therapy.[5]
Testosterone enanthate was introduced for medical use in 1954.[10][4] Along with testosterone cypionate, testosterone undecanoate, and testosterone propionate, it is one of the most widely used testosterone esters.[8][4][5] In addition to its medical use, testosterone enanthate is used to improve physique and performance.[5] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[5]