Treatment-resistant depression
Medical condition / From Wikipedia, the free encyclopedia
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Treatment-resistant depression (TRD) is a term used in psychiatry to describe people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time.[1] Definitions of treatment-resistant depression vary, and they do not include a resistance to psychotherapy. Inadequate response has most commonly been defined as less than 50% reduction in depressive symptoms following treatment with at least one antidepressant medication, although definitions vary widely.[2] Some other factors that may contribute to inadequate treatment are: a history of repeated or severe adverse childhood experiences, early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, cognitive impairment, low income and other socio-economic variables, and concurrent medical conditions, including comorbid psychiatric disorders.[2] Cases of treatment-resistant depression may also be referred to by which medications people with treatment-resistant depression are resistant to (e.g.: SSRI-resistant).[3] In treatment-resistant depression adding further treatments such as psychotherapy, lithium, or aripiprazole is weakly supported as of 2019.[4]
Treatment-resistant depression | |
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Other names | Treatment-refractory depression |
Specialty | Psychiatry |
Symptoms | Depressive mood, anhedonia, low energy |
Complications | Self-harm, suicide |