Trilostane
Chemical compound / From Wikipedia, the free encyclopedia
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Trilostane, sold under the brand name Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans.[2][3][4][5][1] It was withdrawn for use in humans in the United States in the 1990s[6] but was subsequently approved for use in veterinary medicine in the 2000s to treat Cushing's syndrome in dogs.[7] It is taken by mouth.[1]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Vetoryl, others |
Other names | WIN-24,540; 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile |
Routes of administration | By mouth[1] |
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Metabolism | Liver |
Metabolites | 17-Ketotrilostane[1] |
Elimination half-life | Trilostane: 1.2 hours[1] 17-Ketotrilostane: 1.2 hours[1] |
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ECHA InfoCard | 100.033.743 |
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Formula | C20H27NO3 |
Molar mass | 329.440 g·mol−1 |
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