In molecular biology, a two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions.[1] Two-component systems typically consist of a membrane-bound histidine kinase that senses a specific environmental stimulus, and a corresponding response regulator that mediates the cellular response, mostly through differential expression of target genes.[2] Although two-component signaling systems are found in all domains of life, they are most common by far in bacteria, particularly in Gram-negative and cyanobacteria; both histidine kinases and response regulators are among the largest gene families in bacteria.[3] They are much less common in archaea and eukaryotes; although they do appear in yeasts, filamentous fungi, and slime molds, and are common in plants,[1] two-component systems have been described as "conspicuously absent" from animals.[3]
Quick Facts Histidine kinase, Identifiers ...
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Quick Facts His Kinase A (phospho-acceptor) domain, Identifiers ...
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Quick Facts Histidine kinase, Identifiers ...
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Quick Facts Histidine kinase, Identifiers ...
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Quick Facts Signal transducing histidine kinase, homodimeric domain, Identifiers ...
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Quick Facts Histidine kinase N terminal, Identifiers ...
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Quick Facts Osmosensitive K+ channel His kinase sensor domain, Identifiers ...
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