Vesicle-associated membrane protein
Protein family / From Wikipedia, the free encyclopedia
Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.
- VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neurotransmitter release.
- VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
- VAMP5 and VAMP7 participate in constitutive exocytosis.
- VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
- VAMP7 is found both in secretory granules and endosomes.
- VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
- VAMP4 is involved in transport from the Golgi.[1]
Quick Facts Synaptobrevin, Identifiers ...
Synaptobrevin | |||||||||
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Identifiers | |||||||||
Symbol | Synaptobrevin | ||||||||
Pfam | PF00957 | ||||||||
InterPro | IPR016444 | ||||||||
PROSITE | PDOC00368 | ||||||||
SCOP2 | 1sfc / SCOPe / SUPFAM | ||||||||
OPM superfamily | 197 | ||||||||
OPM protein | 4wy4 | ||||||||
Membranome | 198 | ||||||||
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