Zinc L-carnosine
Chelating agent containing zinc and carnosine / From Wikipedia, the free encyclopedia
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Zinc L-carnosine (beta-alanyl-L-histidinato zinc[1]) (N-(3-aminopropionyl)-L-histidinato zinc[2]), often simply called zinc carnosine, and also known as polaprezinc,[3] is a mucosal protective[4][5] chelate compound of zinc and L-carnosine invented by Hamari Chemicals, Ltd.[6][7] It is a quadridentate 1:1 complex of a polymeric nature.[6] Although it contains 23% zinc and 77% L-carnosine by mass,[8] zinc carnosine is a molecule and not a mixture of zinc and L-carnosine.
It is an approved drug requiring a medical prescription in Japan and South Korea where it is clinically used to treat gastric ulcers.[3][9] Clinical studies have also shown its efficacy for oral mucositis, esophagitis, proctitis, taste alteration and dermatitis during and after radiotherapy.[10][11] In the United States, zinc carnosine is regulated as a New Dietary Ingredient, where notification with the US-FDA is required.[12] In Australia, it is regulated as a complementary medicine.[13] In Canada, it is regulated as a Natural Health Product.[14]