Ψ-PEA (psychedelics)

Ψ-Phenethylamines (Ψ-PEA), or psi-phenethylamines (psi-PEA), also known as 4-substituted 2,6-dimethoxyphenethylamines, are a family of psychedelic and related compounds of the phenethylamine family.^[1][2][3] They are positional isomers of the 4-substituted 2,5-dimethoxyphenethylamines (e.g., 2Cs and DOx) and 4-substituted 3,5-dimethoxyphenethylamines (e.g., scalines and 3Cs).^[1][2][3]

TMA-6 (Ψ-TMA-2) is an example of a Ψ-PEA psychedelic.^[1][2][3]

Like the preceding groups or substitution patterns of phenethylamine psychedelics, many Ψ-PEA derivatives are likewise potent serotonergic psychedelics and are known to act as serotonin 5-HT_2A receptor agonists.^[4][1][2][3] Examples of known psychedelic Ψ-PEAs include TMA-6 (Ψ-TMA-2) and Ψ-DOM, Ψ-2C-T-4, Ψ-2C-DFMO, and Ψ-DODFMO.^[4][1][2][3] Conversely, Ψ-2C-O (TMPEA-6) was inactive.^[1][4] Unlike many other psychedelic phenethylamines, Ψ-PEAs such as TMA-6, Ψ-Aleph, and Ψ-Aleph-2 are known to act as potent monoamine oxidase inhibitors (MAOIs).^[1][5]

The Ψ-PEAs are relatively unexplored compared to the other major psychedelic phenethylamine groups.^{[1][2][3][6][7][8][9]} Many Ψ-PEAs have been synthesized or described, but few are known to have been tested in humans.^[1]

List and properties of Ψ-PEAs

Doses and durations of Ψ-PEAs

Compound	Chemical name	Dose	Duration
TMPEA-6 (Ψ-2C-O)	2,4,6-Trimethoxyphenethylamine	>300 mg	Unknown
TMA-6 (Ψ-TMA-2)	2,4,6-Trimethoxyamphetamine	25–50 mg	12–16 hours
Ψ-DOM	4-Methyl-2,6-dimethoxyamphetamine	15–25 mg	6–8 hours
Ψ-2C-T-4	4-Isopropylthio-2,6-dimethoxyphenethylamine	≥12 mg	Unknown
Ψ-2C-DFMO (Ψ-2C-O-35)	4-Difluoromethoxy-2,6-dimethoxyphenethylamine	~17 mg	~18 hours
Ψ-DODFMO	4-Difluoromethoxy-2,6-dimethoxyamphetamine	~10 mg	~20 hours
Refs: [1][4][2][3]

See also

• Substituted methoxyphenethylamine
• 2C, scaline, DOx, 3C
• CT-5172