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2,4,6-Trimethoxyphenethylamine
Pharmaceutical compound From Wikipedia, the free encyclopedia
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2,4,6-Trimethoxyphenethylamine (2,4,6-TMPEA), also known as TMPEA-6, 2C-TMA-6, or ψ-2C-O, is a drug of the phenethylamine and Ψ-PEA families.[1][2][3] It is a positional isomer of mescaline (3,4,5-trimethoxyphenethylamine) and 2C-O (2,4,5-trimethoxyphenethylamine) as well as the α-desmethyl analogue of 2,4,6-trimethoxyamphetamine (TMA-6).[1][2][3]
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Use and effects
According to Daniel Trachsel in 2012, who cited personal communication with P. Rausch in 2009, the drug has been reported to be inactive in humans at a dose of up to 300 mg or more.[4][3] This is similar to the case of 2C-O (inactive at >300 mg), but is in contrast to mescaline (active at ~180–360 mg) as well as TMA-6 (active at 25–50 mg).[4][3][1]
Pharmacology
Unlike mescaline, but similarly to 2C-O, 2,4,6-TMPEA does not appear to be a substrate for amine oxidase.[1][3][5]
History
2,4,6-TMPEA was first described in the scientific literature by 1954.[6][5] Alexander Shulgin mentioned 2,4,6-TMPEA in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved) and stated that its activity in humans was unknown at the time.[1] The compound was encountered as a novel designer drug in Russia in 2023.[7][8]
Derivatives
A variety of derivatives of 2,4,6-TMPEA are known.[3][4][1][2]
See also
- Substituted methoxyphenethylamine
- Trimethoxyphenethylamine
- Ψ-PEA (psychedelics)
- Mescaline (3,4,5-trimethoxyphenethylamine)
- 2C-O (2,4,5-trimethoxyphenethylamine)
- TMA-6 (2,4,6-trimethoxyamphetamine)
References
External links
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