(3-(2-Furoyl)-quinoline-2 carboxaldehyde)

3-(2-Furoyl)-quinoline-2-carboxaldehyde (FQ) is a fluorogenic amine labeling dye that is not fluorescent itself, but reacts with primary amines to form fluorescent products.^[1] It was first reported in 1990.^[2] Cyanide, typically provided via KCN or NaCN salts, is a required co-substrate in the fluorogenic reaction.^[3] It has been used for the detection of amines and peptides, largely in CE-SDS, where it is recognized to reach a silver stain-like high sensitivity via laser-induced fluorescence.^[4] Once bound to protein the excitation wavelength is 480 nm (blue) and the emission wavelength is ~600 nm (orange).^[5]

FQ

Names
IUPAC name 3-(furan-2-carbonyl)quinoline-2-carbaldehyde
Other names FQ, (3-(2-furoyl)-quinoline-2 carboxaldehyde), ATTO-TAG FQ, FQCA
Identifiers
CAS Number	126769-01-5 Y
3D model (JSmol)	Interactive image
ChemSpider	110807
EC Number	635-028-8
PubChem CID	124404
CompTox Dashboard (EPA)	DTXSID10155292
InChI InChI=1S/C15H9NO3/c17-9-13-11(15(18)14-6-3-7-19-14)8-10-4-1-2-5-12(10)16-13/h1-9H Key: PNCHURHVMDRFTR-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)C=C(C(=N2)C=O)C(=O)C3=CC=CO3
Properties
Chemical formula	C15H9NO3
Molar mass	251.241 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Reaction

See also

• CBQCA
• Fluorescamine
• Py-1