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2,5-didehydrogluconate reductase
Class of enzymes From Wikipedia, the free encyclopedia
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In enzymology, a 2,5-didehydrogluconate reductase (EC 1.1.1.274) is an enzyme that catalyzes the chemical reaction
- 2-dehydro-D-gluconate + NADP+ 2,5-didehydro-D-gluconate + NADPH + H+
Thus, the two substrates of this enzyme are 2-dehydro-D-gluconate and NADP+, whereas its 3 products are 2,5-didehydro-D-gluconate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase. Other names in common use include 2,5-diketo-D-gluconate reductase, and YqhE reductase.
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Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VP5.
References
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