2,5-didehydrogluconate reductase

In enzymology, 2,5-didehydrogluconate reductase (EC 1.1.1.274) is an enzyme that catalyzes the chemical reaction

2-dehydro-D-gluconic acid

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

2,5-didehydro-D-gluconic acid

+ NADPH

 

2,5-didehydrogluconate reductase
Identifiers
EC no.	1.1.1.274
CAS no.	95725-95-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 2-dehydro-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 2,5-didehydro-D-gluconic acid, reduced NADPH, and a proton.^[1][2][3][4]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-dehydro-D-gluconate:NADP⁺ 2-oxidoreductase. Other names in common use include 2,5-diketo-D-gluconate reductase, and YqhE reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VP5.