2-Fluoromethcathinone

2-Fluoromethcathinone (2-FMC), also known as 2-flephedrone, is a psychostimulant and designer drug of the cathinone family.^[1][2][3][4] It acts as a dopamine and norepinephrine releasing agent (NDRA).^[4]

2-Fluoromethcathinone

Clinical data
Other names	2-FMC; 2-Fluoromethylcathinone; 2-Fluoro-N-methylcathinone; 2-Flephedrone
Drug class	Stimulant; Norepinephrine–dopamine releasing agent
Identifiers
IUPAC name 1-(2-fluorophenyl)-2-(methylamino)propan-1-one
CAS Number	1186137-35-8
PubChem CID	71316821
ChemSpider	37701826
UNII	7NLX9J64KY
CompTox Dashboard (EPA)	DTXSID401017070
Chemical and physical data
Formula	C10H12FNO
Molar mass	181.210 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C(=O)C1=CC=CC=C1F)NC
InChI InChI=1S/C10H12FNO/c1-7(12-2)10(13)8-5-3-4-6-9(8)11/h3-7,12H,1-2H3 Key:DCMOUMKIDLRIBO-UHFFFAOYSA-N

Pharmacology

The drug has an EC₅₀Tooltip half-maximal effective concentration for dopamine release of 48.7 nM and induces 85% release of norepinephrine at a concentration of 10 μM.^[4] For comparison, the EC₅₀ values of methcathinone are 49.9 nM for dopamine release and 22.4 nM for norepinephrine release and it induces 100% release of norepinephrine at a concentration of 10 μM.^[4][5] Hence, compared to methcathinone, 2-FMC appears to be relatively more selective or efficacious for induction of dopamine release over norepinephrine release.^[4][5] It is notable in this regard that selective dopamine releasing agents are largely unknown.^[6][4]

See also

• 3-Methoxymethcathinone
• 3-Fluoromethcathinone
• 4-Fluoromethcathinone (flephedrone)
• 2-Fluoromethamphetamine