2-MDP

2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The levo or (−)-isomer is the active form of the drug.^[1][2] It also has stimulant effects, having only around one third the potency of amphetamine by weight, but with a long duration of action, lasting more than 24 hours from a single oral dose.^[3]

2-MDP

Identifiers
IUPAC name 3-amino-2-methyl-1,1-di(phenyl)propan-1-ol
CAS Number	14326-31-9 Y HCl: 14185-05-8 Y
PubChem CID	26538
ChemSpider	24719 Y
UNII	B6FTK35FGC HCl: TJH732RKT9 Y
CompTox Dashboard (EPA)	DTXSID90912320
Chemical and physical data
Formula	C16H19NO
Molar mass	241.334 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(c1ccccc1)(c2ccccc2)C(C)CN
InChI InChI=1S/C16H19NO/c1-13(12-17)16(18,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,13,18H,12,17H2,1H3 Y Key:XGYCHIPEPHYUIH-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Effects

The therapeutic action is said to exhibit appetite suppressant- and antidepressant-like activity.^[4]

Synthesis

2-MDP synthesis

In a variation of the nitrile-aldol reaction, combination of benzophenone (1) and propionitrile (2), in the presence of sodamide base and ethyl ether solvent, leads to 3-hydroxy-2-methyl-3,3-diphenylpropanenitrile (3).^[5] The reduction of the intermediate nitrile group with lithium aluminium hydride completes the synthesis of 2-MDP (4).