2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase (EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconic acid

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid

+ NADPH

 

2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
Identifiers
EC no.	1.1.1.126
CAS no.	37250-55-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid, reduced NADPH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP⁺ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.