2-dehydropantoate 2-reductase

In enzymology, a 2-dehydropantoate 2-reductase (EC 1.1.1.169) is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NADP⁺ ${\displaystyle \rightleftharpoons }$ 2-dehydropantoate + NADPH + H⁺

2-dehydropantoate 2-reductase
Identifiers
EC no.	1.1.1.169
CAS no.	37211-74-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (R)-pantoate and NADP⁺, whereas its 3 products are 2-dehydropantoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP⁺ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.