2-dehydropantolactone reductase (A-specific)

In enzymology, 2-dehydropantolactone reductase (A-specific) (EC 1.1.1.168) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

2-dehydropantolactone

+ NADPH

 

2-dehydropantolactone reductase (A-specific)
Identifiers
EC no.	1.1.1.168
CAS no.	37211-75-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are (R)-pantolactone and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 2-dehydropantolactone, reduced NADPH, and a proton.^[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP⁺ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).