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2-deoxy-D-gluconate 3-dehydrogenase
Class of enzymes From Wikipedia, the free encyclopedia
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2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) is an enzyme that catalyzes the chemical reaction
- 2-deoxy-D-gluconate + NAD+ 3-dehydro-2-deoxy-D-gluconate + NADH + H+
Thus, the two substrates of this enzyme are 2-deoxy-D-gluconate and NAD+, whereas its 3 products are 3-dehydro-2-deoxy-D-gluconate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.
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Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E.
References
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