2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP⁺ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP⁺ 2-oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP⁺ ${\displaystyle \rightleftharpoons }$ 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H⁺

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Identifiers
EC no.	1.1.1.312
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.