2-oxoadipate reductase

In enzymology, 2-oxoadipate reductase (EC 1.1.1.172) is an enzyme that catalyzes the chemical reaction

(R)-2-hydroxyadipic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

2-Oxoadipic acid

+ NADH

 

2-oxoadipate reductase
Identifiers
EC no.	1.1.1.172
CAS no.	61116-21-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are (R)-2-hydroxyadipic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 2-oxoadipic acid, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-hydroxyadipate:NAD⁺ 2-oxidoreductase. Other names in common use include 2-ketoadipate reductase, alpha-ketoadipate reductase, and 2-ketoadipate reductase.