2C-T-9

2C-T-9, also known as 4-tert-butylthio-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.^[1][2][3]

2C-T-9

Clinical data
Other names	4-tert-Butylthio-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-tert-butylthiophenethylamine
Routes of administration	Oral[1][2]
Drug class	Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Duration of action	12–18 hours[1][2]
Identifiers
CAS Number	207740-28-1
PubChem CID	44349799
ChemSpider	23206245
CompTox Dashboard (EPA)	DTXSID301349216
Chemical and physical data
Formula	C14H23NO2S
Molar mass	269.40 g·mol−1
3D model (JSmol)	Interactive image
SMILES NCCc1cc(OC)c(cc1OC)SC(C)(C)C
InChI InChI=1S/C14H23NO2S/c1-14(2,3)18-13-9-11(16-4)10(6-7-15)8-12(13)17-5/h8-9H,6-7,15H2,1-5H3 Key:PSVDMTZXLJTPNX-UHFFFAOYSA-N

Use and effects

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved), the dose range of 2C-T-9 is 60 to 100 mg and its duration is 12 to 18 hours.^[1][2][4] Its effects included impairment such that one would not feel comfortable to drive, more effects "to the body than to the head", "body energy", sleeping difficulties, and hangover.^[1] The drug did not produce psychedelic visuals.^[1] One of the reports of 2C-T-9 was rated as a '+++' on the Shulgin Rating Scale.^[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

2C-T-9 has been found to act as a serotonin 5-HT_2A receptor agonist with modest potency (EC₅₀Tooltip half-maximal effective concentration = 150 nM).^[5] The drug failed to produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents at the assessed dose of 3 mg/kg, which was said to parallel its known low potency in humans.^[5]

History

2C-T-9 was first described in the scientific literature by Alexander Shulgin and colleagues in 1991.^[3][1] This included in a journal article^[3] and in his book PiHKAL (Phenethylamines I Have Known and Loved).^[1]

See also

• Substituted methoxyphenethylamine
• 2C (psychedelics)