3,4-dihydroxy-2-butanone-4-phosphate synthase

The enzyme 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (RibB) EC 4.1.99.12 catalyses the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate, the latter serving as the biosynthetic precursor for the xylene ring of riboflavin.^[1] In Photobacterium leiognathi, the riboflavin synthesis genes ribB (DHBP synthase), ribE (riboflavin synthase), ribH (lumazine synthase) and ribA (GTP cyclohydrolase II) all reside in the lux operon.^[2] RibB is sometimes found as a bifunctional enzyme with GTP cyclohydrolase II that catalyses the first committed step in the biosynthesis of riboflavin. No sequences with significant homology to DHBP synthase are found in the metazoa.

DHBP_synthase
crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase gold derivative
Identifiers
Symbol	DHBP_synthase
Pfam	PF00926
InterPro	IPR000422
SCOP2	1iez / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary