3-Deazaneplanocin A

3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has effects in vitro against a variety of different tumor cell lines.^{[1][2][3][4][5]}

3-Deazaneplanocin A

Names
Preferred IUPAC name (1S,2R,5R)-5-(6-Amino-9H-purin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Identifiers
CAS Number	102052-95-9 Y
3D model (JSmol)	Interactive image
ChemSpider	65874
ECHA InfoCard	100.224.238
PubChem CID	73087
UNII	544SH4020S Y
CompTox Dashboard (EPA)	DTXSID30144562
InChI InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1 Key: OMKHWTRUYNAGFG-IEBDPFPHSA-N InChI=1/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1 Key: OMKHWTRUYNAGFG-IEBDPFPHBD
SMILES n3ccc1c(ncn1[C@@H]2/C=C(/CO)[C@@H](O)[C@H]2O)c3N
Properties
Chemical formula	C12H14N4O3
Molar mass	262.265
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease,^[6] apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus.^[7][8]