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3-Methoxy-4-methylamphetamine

Entactogen and psychedelic drug of the phenethylamine and amphetamine classes From Wikipedia, the free encyclopedia

3-Methoxy-4-methylamphetamine
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3-Methoxy-4-methylamphetamine (MMA) is an entactogen and psychedelic drug of the phenethylamine and amphetamine classes.[1][2] It was first synthesized in 1970[1] and was encountered as a street drug in Italy in the same decade.[3] MMA was largely forgotten until being reassayed by David E. Nichols as a non-neurotoxic MDMA analogue in 1991,[2] and has subsequently been sold as a designer drug on the internet since the late 2000s.[citation needed]

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In animal studies, MMA fully substitutes for MDMA and MBDB, partially substitutes for LSD, and does not substitute for amphetamine in rodent drug discrimination tests.[2] However, in another study, MMA fully substituted for dextroamphetamine in such tests.[4] Additionally, it has been shown to be a potent and highly selective serotonin releasing agent (SSRA) and does not produce serotonergic neurotoxicity in rodents.[5][2][6] These data appear to confer a profile of MMA as a selective serotonin releasing agent (SSRA) and serotonin 5-HT2A receptor agonist.[2]

In humans, MMA has been reported to be hallucinogenic, "quite dypshoric", and long-lasting.[7] The active doses have been reported to be 40 to 60 mg.[7] Capsules containing 140 mg have been encountered as a designer drug in Italy in the 1980s.[7]

The 2-aminoindane analogue of MMA is 5-methoxy-6-methyl-2-aminoindane (MMAI).[8][6]

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