3-dehydro-L-gulonate 2-dehydrogenase

In enzymology, 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:

3-dehydro-L-gulonic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

2,3-diketogulonic acid

+ NADH

 

3-dehydro-L-gulonate 2-dehydrogenase
3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli
Identifiers
EC no.	1.1.1.130
CAS no.	37250-61-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 3-dehydro-L-gulonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 2,3-diketogulonic acid, reduced NADH, and a proton. The enzyme can also use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.