3-hexulose-6-phosphate synthase

3-hexulose-6-phosphate synthase (EC 4.1.2.43, D-arabino-3-hexulose 6-phosphate formaldehyde-lyase, 3-hexulosephosphate synthase, 3-hexulose phosphate synthase, HPS) is an enzyme with systematic name D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming).^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

D-arabino-hex-3-ulose 6-phosphate ${\displaystyle \rightleftharpoons }$ D-ribulose 5-phosphate + formaldehyde

3-hexulose-6-phosphate synthase
Identifiers
EC no.	4.1.2.43
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme requires Mg²⁺ or Mn²⁺ for maximal activity.