3-hydroxyanthranilate oxidase

In enzymology, a 3-hydroxyanthranilate oxidase (EC 1.10.3.5) (also called 3-HAO) is an enzyme that catalyzes the chemical reaction:^[1]

3-hydroxyanthranilate + O₂ ${\displaystyle \rightleftharpoons }$ 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H₂O₂

3-hydroxyanthranilate oxidase
Identifiers
EC no.	1.10.3.5
CAS no.	37256-53-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O₂, whereas its two products are 6-imino-5-oxocyclohexa-1,3-dienecarboxylate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen oxidoreductase. This enzyme is also called 3-hydroxyanthranilic acid oxidase.