3-hydroxypropionate dehydrogenase

In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

3-Hydroxypropionic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

3-Oxopropanoic acid

+ NADH

 

3-hydroxypropionate dehydrogenase
Identifiers
EC no.	1.1.1.59
CAS no.	9028-59-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are 3-hydroxypropionic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 3-oxopropanoic acid, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD⁺ oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.