4-AcO-DET

4-AcO-DET, also known as 4-acetoxy-N,N-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelic tryptamine. It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.^[1]

4-AcO-DET

Clinical data
Other names	4-Acetoxy-DET; 4-Acetoxy-N,N-diethyltryptamine; Ethacetin; Ethylacybin
Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Class A
Identifiers
IUPAC name 3-(2-Diethylaminoethyl)-1H-indol-4-yl acetate
CAS Number	1135424-15-5 N
PubChem CID	24801867
ChemSpider	21106239 Y
UNII	43U8799479
CompTox Dashboard (EPA)	DTXSID60647359
Chemical and physical data
Formula	C16H22N2O2
Molar mass	274.364 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(OC1=CC=CC2=C1C(CCN(CC)CC)=CN2)=O
InChI InChI=1S/C16H22N2O2/c1-4-18(5-2)10-9-13-11-17-14-7-6-8-15(16(13)14)20-12(3)19/h6-8,11,17H,4-5,9-10H2,1-3H3 Y Key:ODVLAYUXIAMBFN-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Use and effects

4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours.^[2] The free base is also active when smoked in a dose range of 5–20 mg.^[1] Smoking 4-acetoxy-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.^[specify]

Pharmacology

It is expected that the compound is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.

Society and culture

Legal status

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-AcO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-acetoxi-N,N-dietyltryptamin (4-AcO-DET), making it illegal to sell or possess.^[3]