4-Chloroisobutyrylfentanyl

4-Chloroisobutyrylfentanyl (para-Chloroisobutyrylfentanyl, 4-Cl-iBF) is an opioid analgesic that is an analog of fentanyl,^[1] and has been sold online as a designer drug.^[2][3]

4-Chloroisobutyrylfentanyl

Legal status
Legal status	US: Schedule I Illegal in Finland and Sweden
Identifiers
IUPAC name 2-Methyl-N-(4-chlorophenyl)-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide
CAS Number	244195-34-4
PubChem CID	100974915
ChemSpider	81367196
UNII	6DS2GH6V2D
Chemical and physical data
Formula	C23H29ClN2O
Molar mass	384.95 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3ccccc3CCN(CC1)CCC1N(C(=O)C(C)C)c(cc2)ccc2Cl
InChI InChI=InChI=1S/C23H29ClN2O/c1-18(2)23(27)26(21-10-8-20(24)9-11-21)22-13-16-25(17-14-22)15-12-19-6-4-3-5-7-19/h3-11,18,22H,12-17H2,1-2H3 Key:YWHLYGSHOQKCJG-UHFFFAOYSA-N

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[4] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.^[5]

Legal status

para-Chloroisobutyrylfentanyl has been a Schedule I controlled drug in the United States since 1 February 2018.^[6] It was banned in Finland in September 2017,^[7] and in Sweden in October 2017.^[8]

See also

• 4-Bromofentanyl
• Acetylfentanyl
• Butyrfentanyl
• Furanylfentanyl
• List of fentanyl analogues